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Clarithromycin should not be used in pregnant women except where no alternative therapy is appropriate, particularly during the first trimester of pregnancy. If the patient becomes pregnant while receiving clarithromycin, the patient should be informed of the potential hazard to the fetus (see Use in Pregnancy & Lactation).
The concomitant use of clarithromycin and drugs metabolized by CYP3A and/or transported by P-glycoprotein (P-gp) may result in significant safety concerns (see Interactions).
